Type de Publication Article
    Titre Dynamic modelling of hepatitis C virus transmission among people who inject drugs: a methodological review
    Auteurs Cousien A. | Tran V. C. | Deuffic-Burban S. | Jauffret-Roustide M. | Dhersin J. S. | Yazdanpanah Y.
    Revue J Viral Hepat
    Titre periodique abbreviation Journal of viral hepatitis
    Résumé Equipment sharing among people who inject drugs (PWID) is a key risk factor in infection by hepatitis C virus (HCV). Both the effectiveness and cost–effectiveness of interventions aimed at reducing HCV transmission in this population (such as opioid substitution therapy, needle exchange programmes or improved treatment) are difficult to evaluate using field surveys. Ethical issues and complicated access to the PWID population make it difficult to gather epidemiological data. In this context, mathematical modelling of HCV transmission is a useful alternative for comparing the cost and effectiveness of various interventions. Several models have been developed in the past few years. They are often based on strong hypotheses concerning the population structure. This review presents compartmental and individual-based models to underline their strengths and limits in the context of HCV infection among PWID. The final section discusses the main results of the papers.
    Pages 213-229
    Volume 22
    Numéro 3
    Mots clés antiviral treatment | dynamic modelling | harm reduction policies | hepatitis C | injecting drug users
    Année 2015
    Url http://dx.doi.org/10.1111/jvh.12337
    Electronic resource num 10.1111/jvh.12337
    ISBN 1365-2893