Type de Publication Article
    Titre Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism
    Auteurs Domart M-C. | Benyamina A. | Lemoine A. | Bourgain C. | Blecha L. | Debuire B. | Reynaud M. | Saffroy R.
    Revue Addiction Biology
    Résumé A variable (GT)n repeat in the 5′-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject–control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10−4). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
    Pages 783-785
    Volume 17
    Numéro 4
    Mots clés Addiction | alcohol-dependence | glutamate | GRIN2A | NMDA | (GT)n repeat
    Année 2012
    Editeur Blackwell Publishing Ltd
    Url http://dx.doi.org/10.1111/j.1369-1600.2011.00321.x
    Electronic resource num 10.1111/j.1369-1600.2011.00321.x
    ISBN 1369-1600