Type de Publication Article
    Titre Polydrug use during pregnancy and neonatal outcome: Data from a ten-year retrospective French study
    Auteurs Simmat-Durand L. | Lejeune C.
    Revue Journal of Neonatal Nursing
    Résumé Objective To analyse the modalities and consequences of multiple drug use during pregnancy. Methods 170 neonates whose mothers declared using at least two psychoactive substances, in a French hospital, between 1999 and 2008 were studied. Data was obtained from obstetrical, neonatal and addiction file records. Results The identified mothers used on average three products at delivery, mostly tobacco, opiate substitution treatment, cannabis, alcohol and benzodiazepines. The birth cohort effect was very marked. The women using more than four substances experienced significantly more pregnancy terminations in their lives. Their newborns showed significant differences in terms of preterm births (31.3% < 37 weeks), birth weights, sizes and neonatal abstinence syndromes (37.5% had a Lipsitz score >9). They were twice as likely to be taken into foster care. Long hospitalisations were three times more frequent for them (32.8% duration >30 days). Conclusion Multiple drug use in pregnancy is a risk factor resulting in poor outcome whatever the combination of substances.
    Pages 232-240
    Volume 18
    Numéro 6
    Mots clés France | Pregnancy | Polydrug use | Retrospective study
    Année 2012
    Url http://linkinghub.elsevier.com/retrieve/pii/S13551
    ISBN 1355-1841
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